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ФУНКЦИОНАЛЬНАЯ АКТИВНОСТЬ ЛИМФОЦИТОВ У БОЛЬНЫХ ИКСОДОВЫМ КЛЕЩЕВЫМ БОРРЕЛИОЗОМ ВЛИЯНИЕ ВИРУСНОИ ИНФЕКЦИИ КЛЕЩЕВЫМ ЭНЦЕФАЛИТОМ НА ЦИТОГЕНЕТИЧЕСКИЕ ИЗМЕНЕНИЯ И ИММУНОЛОГИЧЕСКИЕ ПРЕДИКТОРЫ БОЛЕЗНИ РОЛЬ ГЕНА GSTM1 В ЦИТОГЕНЕТИЧЕСКИХ ИЗМЕНЕНИЯХ КЛЕТОК КРОВИ и ПАТОЛОГИЧЕСКИХ ИЗМЕНЕНИЯХ СПЕРМАТОЗОИДОВ ПРИ ГРАНУЛОЦИТАРНОМ АНАПЛАЗМОЗЕ ЧЕЛОВЕКА ГЕНЕТИЧЕСКИИ ПОЛИМОРФИЗМ И ЦИТОГЕНЕТИЧЕСКИЕ ИЗМЕНЕНИЯ Т- ЛИМФОЦИТОВ У БОЛЬНЫХ АРТРИТОМ, АССОЦИИРОВАННЫМ В КЛЕЩЕВЫМ БОРРЕЛИОЗОМ КЛИНИЧЕСКИЕ ПОСЛЕДСТВИЯ ИКСОДОВОГО ВЕСЕННЕ-ЛЕТНЕГО КЛЕЩЕВОГО ЭНЦЕФАЛИТА МОРФОФУНКЦИОНАЛЬНЫИ СТАТУС И АДАПТИВНЫЕ ВОЗМОЖНОСТИ ОРГАНИЗМА ПЕРВОКЛАССНИКОВ ШКОЛ г. НЕФТЕЮГАНСКА ТЮМЕНСКОИ ОБЛАСТИ Материалы трудов участников 14-ой международной выездной конференции русскоязычных ученых в Китае (Sanya, Haynan Island) "Современный мир, природа и человек", том 8, №3. ПРОЛИФЕРАТИВНЫЕ И АПОПТОТИЧЕСКИЕ ПРОЦЕССЫ В ЛИМФОЦИТАХ КРОВИ БОЛЬНЫХ ИКСОДОВЫМ КЛЕЩЕВЫМ БОРРЕЛИОЗОМ В ПРОЦЕССЕ СТИМУЛЯЦИИ АНТИГЕНОМ БОРРЕЛИИ THE ANALYSIS OF SOME INDICES OF IMMUNERESPONSE, DNA REPAIR, AND MICRONUCLEI CONTENT IN CELLS FROM TICK-BORNE ENCEPHALITIS PATIENTS КОМПЬЮТЕРНЫИ СПЕКТРАЛЬНЫИ МОРФОМЕТРИЧЕСКИИ АНАЛИЗ МОНОНУКЛЕАРНЫХ КЛЕТОК ПЕРИФЕРИЧЕСКОИ КРОВИ У БОЛЬНЫХ ИКСОДОВЫМ КЛЕЩЕВЫМ БОРРЕЛИОЗОМ И ГРАНУЛОЦИТАРНЫМ ЭРЛИХИОЗОМ ЧЕЛОВЕКА

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INFLUENCE OF ENVIRONMENTAL FACTORS ON REPRODUCTIVE HEALTH OF WOMEN

Автор Nikiforov V.A., Sharov N.V., Starkov L.V., Nikiforov A.A.   
15.02.2011 г.
GOU VPO "Bratsk State University" (Bratsk)

Эта статья опубликована сборнике научных трудов "Проблемы и перспективы современной науки" с материалами Четвертой Международной Телеконференции "Фундаментальные науки и практика" - Том 3 - №1. - Томск - 2011.

 


Recently the problem of violations of reproductive functions of the body - reproductive health - was particularly disturbing sound. Reproductive health indicators are increasingly being considered at present as a sensitive indicator of ecological trouble [YP Gichev, 2007]. An overwhelming number of maximum permissible concentration (MPC) of chemical substances was set without regard to their effect on pregnancy and the reproductive system of the human body. At the same time, literature data indicate that pregnancy significantly alters the reactivity of the female body, and often increases its sensitivity to adverse environmental factors, among which primarily include chemicals. Must be borne in mind that some substances reach the environment in low concentrations, may interact with each other, leading to a summation and potentiation of toxic effect. Among the main criteria for the activity of pollutants in the problem of contamination of biological chain is essential given its ability to cause fetal death, decreased fertility and congenital malformations [M. J. Studenikina, 2001]. Facts about these or other reproductive harm due to the influence of various pollutants have been obtained in industrial agglomerations of many regions of the Russian Federation and in several industrial cities.
Currently, the Bratsk Irkutsk Region has developed environmental emergencies. The city is located in the heart of the East-Siberian region and is a major industrial hub EFR, its territory is divided into three districts - Central, Padunsky and Right Bank. The greatest amount of specific pollutants enter the atmosphere from sources of non-ferrous metallurgy, pulp and paper industry, vehicles. Very high levels of pollution due to high content of formaldehyde in ambient air, carbon disulfide, benzo (a) pyrene, nitrogen dioxide, hydrogen fluoride. Table 1 shows the priority pollutants Bratsk and their effects on the reproductive system [VM Boev, VN Dunayev, VN Averyanov et al, 2004, BA Gurevich, SL Avaliani, GI Tikhonov, 2004, MF Savchenkov, 2002, FF Dautov, 2002, VM Boev, 2004].

Table 1 - Contaminants that violate the reproductive Women's Health

Name of substance

Violation

Hydrogen sulfide

Diseases of the genitourinary system, changing the timing of fetal development, fetal hypotrophy, congenital anomalies

Fluoride

Perinatal mortality, congenital anomalies, congenital malformations

Formaldehyde

Carcinogenic effect, spontaneous abortions, decreased indices of physical development, birth defects, malformations

Sulfur dioxide

Asphyxia, embryo-toxic effects, congenital malformations

Carbon monoxide

Asphyxia, embryo-toxic effects, congenital malformations

Nitrogen dioxide

Embryo-toxic effects, congenital malformations

Benzo (a) pyrene

Birth defects, developmental defects, cancers of the reproductive system

The effect of the summation

Hydrogen sulfide,

Formaldehyde,

Carbon monoxide

The birth of LBW infants

Sulfur dioxide,

Nitrogen dioxide,

Benzo (a) pyrene

Birth krupnovesnyh children

 


Causal and effectual relation between the pollution and unhealthy influence on reproducting health allows to expose the effecting degree of unhealthy influense concentrations of number matters on frequency of spontaneous abortions, stillborn, genitor-urinary diseases, of little weight and great weight of new-borns, boetus's asphyxia and number of inborn anomalys. Statistical analysis of materials of town's timber industrial department and Bratsk's centre of state monitoring service datas allowed to make next conclusions with using the methods of mathematicals analysis and estimation of relative risk. The quantity spontaneous abortions and stillborns depends on concentration of the formaldehyde and the hydrogen fluoride on 46,99 per cent and 63,27 per cent in the Central area and 50,4 per cent and 64,0 per cent in the Padun area accordingly.
The carbon's oxide and the formaldehyde; the sulphur's dioxide and benzopiren; the carbon's oxide and the sulphur's dioxide; the sulphur's dioxide, the formaldehyde and the hydrogen fluoride have a summation's effect, it conductives to increase of quantity of little weight and great weight children and new-borns with asphyxia and with inborn anomalus. The contrations of the sulphurettretted hydrogen, the formaldehyde, the carbon's oxide, the sulphur's dioxide, a nitrous oxide and the hydrogen fluoride are not the main factors in the forming of frequency of cases in origin of inborn anomalys, but its are rery important. The influence of the sulphuretted hudrogen, the formaldehyde and the carbon's oxide on the forming of little weight of new-borns and also the influence of the sulphur's dioxide, a nitrous and benzopiren on the forming of great weight of new-borns are increased annually. The risk's estimation to population's reproducting health from the technogen pollution's influence is characterized as very higt. In the reproductive health of women stands out except for perinatal pathology and pathology of newborn infants, and perinatal and infant mortality, and several criteria of ecological trouble:
• termination of pregnancy;
• toxicosis of the second half of pregnancy;
• spontaneous abortion;
• premature birth;
• premature expulsion of the fetal treatment;
• anomalies of labor activity.
Long-term study found that women residing in a polluted industrial city, the third generation show the so-called "cumulative effect" of an adverse environment of harmful pollutants, which is expressed in reducing their reproductive capacity, frequent manifestations of pathology of pregnancy, childbirth and the postpartum period, as well as in slow recovery from childbirth. In the context of unfavorable demographic situation in Russia, the above facts indicate that an important reserve for improvement is the need to government decision making and implementation of concrete actions aimed at improving the environment.

Последнее обновление ( 12.04.2011 г. )
 
 
 
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