蓄耱 玎犷脲忄屐铖蜩 狃铐蹊嚯铋 囫蜢铋 (晾) � 疋�玎眄 � 龛� 铐铎梓羼觇� 簌屦� 恹琨忄弪 礤钺躅滂祛耱� 疣琊噌铗觇 翦牝桠睇� 戾蝾漕� 镥疴梓眍� 镳铘桦嚓蜩觇 溧眄铋 镟蝾腩汨� [2, 3]. 佯邃� 疣珉梓睇� 磬镳噔脲龛� 镳铘桦嚓蜩觇 晾 镳桀痂蝈蝽铄 戾耱� 玎龛爨弪 镳邂屙蜩忭�� 羿痨嚓铗屦囡��. 务钺屙眍耱 溧眄钽� 戾蝾溧 �怆�弪�� 镱蝠遽眍耱� � 疱汶囔屙蜩痤忄眄 镱赅玎龛�� � 钺铖眍忄眄铎 纛痨桊钼囗梃 沭箫� 痂耜� 镱 疣玮栩棹 晾 [4]. 软蝈疱� 镳邃耱噔��弪 镱桉� 漕镱腠栩咫 徼铍钽梓羼觇� 爨痍屦钼, � 蝾� 麒耠� 铖钺屙眍耱彘 沐礤蜩麇耜桴 篦囫蜿钼, 觐滂痼桴 徨腙� 桁祗眍腩汨麇耜桴 嚆屙蝾� 囹铒梓羼觐泐 忸耧嚯屙�� [1].

皱朦� 桉耠邃钼囗�� �怆�腩顸 篑蜞眍怆屙桢 痤腓 镱腓祛痿桤爨 -703�/� 沐磬 IL5 赅� 徼铍钽梓羼觐泐 爨痍屦� 潆� 镳邂屙蜩忭铋 羿痨嚓铗屦囡梃 晾 � 溴蝈� � 囹铒梓羼觇� 溴痨囹栩铎 (滥).
橡钽疣祆� 铖簌羼蜮��豚顸 磬 徉珏 钺豚耱眍泐 溴蝰觐泐 鲥眚疣 觌桧梓羼觐� 桁祗眍腩汨� � 嚯脲疸铍钽梃 (吾豚耱磬� 溴蝰赅� 犷朦龛鲟, �. 翌祚�) � 耦耱��豚 桤 钿眍祛戾眚眍泐 � 镳铖镥牝桠眍泐 桉耠邃钼囗��:
沭箫镟 1 钿眍祛戾眚眍泐 磬犭屙��: 犷朦睇� 滥 (n=23, 耩邃龛� 忸琊囫� 9,4±0,28 脲�);
沭箫镟 2 镳铖镥牝桠眍泐 磬犭屙��: 犷朦睇� 滥. 泥眄�� 恹犷痍� 猁豚 疣礓铎桤桊钼囗� 磬 2 镱溷痼镲�:
沭箫镟 2�: (n=43, 耩邃龛� 忸琊囫� 2,31±0,25 脲�); 镟鲨屙螓 镱塍鬣腓 镳邂屙蜩忭簋 羿痨嚓铗屦囡棹 狃铐蹊嚯铋 囫蜢�;
沭箫镟 2�: (n=44, 耩邃龛� 忸琊囫� 2,26±0,45 脲�); 犷朦睇� 镳邂屙蜩忭簋 羿痨嚓铗屦囡棹 礤 镱塍鬣腓;
沭箫镟 3 钿眍祛戾眚眍泐 磬犭屙��: 犷朦睇� � 耦麇蜞眄铋 镟蝾腩汨彘 (滥 � 晾) (n=71, 耩邃龛� 忸琊囫� 9,9±0,57 脲�).
灭箫稃 1 � 3 钿眍祛戾眚眍泐 磬犭屙�� 猁腓 耵铕扈痤忄睇 潆� 桤篦屙�� 疣耧疱溴脲龛� 沐礤蜩麇耜桴 镳邃桕蝾痤� 晾 � 镟鲨屙蝾� � 桤铍桊钼囗睇� 滥 � 犷朦睇� � 耦麇蜞眄铋 镟蝾腩汨彘 (滥 � 晾).
灭箫镟 4: 觐眚痤朦磬� (n=150, 耩邃龛� 忸琊囫� 7,61±1,23 脲�).

填脲牦��痦�-沐礤蜩麇耜栝 戾蝾� 囗嚯桤� 怅膻鬣� 桉耠邃钼囗桢 镱腓祛痿桤爨 -703�/� 沐磬 IL5. 诣镨痤忄龛� 镱腓祛痿桤爨 镳铊玮钿桦� � 镱祛� 疱耱痂牿桀眄钽� 囗嚯桤� 现�-镳钿箨蝾�, 耦溴疰帙桴, 镳� 磬腓麒� 嚯脲�� �, 襦轵 箸磬忄龛� 潆� 漕眢觌遴琨 AlwN 1 (New England Biolabs, 沿�).
孰桧桕�-羿痨嚓铍钽梓羼觐� 桉耠邃钼囗桢 镳屣囵囹� 氰痱尻® (扪� 脏痨�, 铃朦汨�; 礤镟蝈眚钼囗眍� 磬玮囗桢 - 鲥蜩痂玷�) 镳钼钿桦铖� � 沭箫镥 2; 镟鲨屙螓 磬犭嚯桉� 24 戾��鲟 漕 漕耱桄屙�� 忸琊囫蜞 3 - 4 脲�. 相鲨屙蜞� 沭箫稃 2� 鲥蜩痂玷� 磬珥圜嚯�� � 疱骅戾 镳邂屙蜩忭铋 羿痨嚓铗屦囡梃 � 漕珏 0,25 煦/赉 � 耋蜿� 彐邃礤忭� � 蝈麇龛� 9-12 戾��鲥�. 令朦睇� 沭箫稃 2� 镳铘桦嚓蜩赅 晾 礤 磬珥圜嚯囫�. 羊囹桉蜩麇耜�� 钺疣犷蜿� 镱塍麇眄 溧眄 镳钼钿桦囫� 镳� 镱祛 镟赍蜞 镳钽疣祆 «STATISTICA for Windows 6. 0».

� 镳铞羼皴 24 戾��鲥� 磬犭屙�� 晾 耵铕扈痤忄豚顸 � 11,6% 镟鲨屙蝾� (n=5) 沭箫稃 2�, � 蝾 怵屐� 赅� � 沭箫镥 2� 溧眄 镱赅玎蝈朦 耦耱噔桦 27,3% (n=12). 佯邃� 镟鲨屙蝾�, 镱塍麒怿桴 牦瘃 镳邂屙蜩忭铋 羿痨嚓铗屦囡梃, 铗戾鬣腓顸 耱囹桉蜩麇耜� 珥圜桁� 犷脲� 镱玟龛� 耩铌� 纛痨桊钼囗�� 晾: 3,4±1,14 脲� � 耩噔礤龛� 耦 耩邃龛� 忸琊囫蝾� 溴狺蜞 晾 � 沭箫镥 2� - 2,0±0,77 脲�. 橡钼邃屙磬� 羿痨嚓铗屦囡�� 蜞赕� 镳桠钿桦� � 耥桄屙棹 鬣耱铗� 狃铐躅钺耱痼牝桠眍泐 耔礓痤爨 耩邃� 犷朦睇� 沭箫稃 2�.

碾� 桤篦屙�� 怅豚溧 镱腓祛痿桤爨 -703�/� 沐磬 IL5 � 纛痨桊钼囗桢 晾 铞屙桠嚯� 疣耧疱溴脲龛� 沐眍蜩镱� � 恹犷痍圊 犷朦睇� 桤铍桊钼囗睇� 滥, � 镟鲨屙蝾� � 晾 � 滥 � � 沭箫镥 玟铕钼 溴蝈� (蜞犭. 1). 令朦睇� 滥 猁腓 镳邃耱噔脲睇 溴螯扈 沭箫稃 1, � 蜞赕� 犷朦睇扈, 礤 镱塍鬣怿桁� 镳邂屙蜩忭簋 羿痨嚓铗屦囡棹, � 觐蝾瘥� 玎 镥痂钿 磬犭屙�� 礤 耵铕扈痤忄豚顸 晾 (沭箫镟 2�). 吾磬痼驽眍 镳孱犭噤囗桢 泐祛玷泐� 703蜒 � 沭箫镥 犷朦睇� 滥 � 晾 � 耩噔礤龛� � 觐眚痤脲�. 朽珉梓栝 � 疣耧痤耱疣礤眄铖蜩 沐眍蜩镱� 戾驿� 觐眚痤朦眍� 沭箫镱� � 恹犷痍铋 镟鲨屙蝾� � 滥 礤 镱塍麇眍.
理嚯桤 鬣耱铗 怦蝠鬻噱祛耱� 嚯脲脲� � 桤篦噱禧� 沭箫镟� 镱玮铍桦 恹�忤螯 镳孱犭噤囗桢 眍耔蝈脲� 嚯脲�� -703� 耩邃� 镟鲨屙蝾�, 耱疣溧桴 晾 � 滥, � 耩噔礤龛� 耦 玟铕钼� 腓鲟扈. 奏耱铗� 嚯脲脲� � 恹犷痍� 犷朦睇� 滥 镳嚓蜩麇耜� 礤 铗腓鬣腩顸 铗 蜞觐恹� � 玟铕钼 腓�.

亦觇� 钺疣珙�, 眍耔蝈朦耱忸 嚯脲�� -703� 沐磬 IL5 �怆�弪�� 羿牝铕铎 痂耜� 纛痨桊钼囗�� 晾, 眍 礤 滥. 蒡铗 沐礤蜩麇耜栝 羿牝铕 祛骓� 疣耨爨蝠桠囹� 赅� 漕镱腠栩咫 徼铍钽梓羼觇� 爨痍屦 疣玮栩�� 晾 � 镟鲨屙蝾� � 嚯脲疸梓羼觇� 镱疣驽龛屐 觐骅.
橡铖镥牝桠眍� 磬犭屙桢 镱赅玎腩, 黩� 耩邃� 犷朦睇�, 镱塍麒怿桴 牦瘃 镳邂屙蜩忭铋 羿痨嚓铗屦囡梃, � 觐蝾瘥� � 铌铐鬣龛� 镳钽疣祆� 疣玮桦囫� 晾 (n=5), 铗戾鬣腩顸 戾睃� 麒耠� 眍耔蝈脲� 嚯脲�� -703�, 麇� � 沭箫镥 3; � 溴祛眈蝠桊箦� 翦牝桠眍耱� 羿痨嚓铒痤翳豚牝桕� 晾 耩邃� 钺豚溧蝈脲� 嚯脲�� -703� 沐磬 IL5 (蜞犭. 2). 碾� 镱塍麇龛� 犷脲� 蝾黜 溧眄 桉耠邃钼囗�� 礤钺躅滂祛 漕镱腠栩咫铄 疣聒桊屙桢 镳铖镥牝桠眍� 沭箫稃.